Flexible pressure and thermal sensors can serve as the “electronic skin” for a robotic system to achieve intelligent functions such as grasping control, objects recognition, human-machine interaction, and environmental thermal sensing. Recently, we developed flexible pressure and thermal sensor arrays with good flexibility and high sensitivity. The developed piezoresistive pressure sensor consists of a substrate with the patterned electrodes and an elastomer slab with the designed surface microstructure and electrically conductive coating layer. The ultrasensitive flexible thermal sensor array is based on our newly developed high-thermopower ionic hydrogel consisting of polyquaternium-10 (PQ-10), a cellulose derivative, as the polymer matrix and sodium hydroxide (NaOH) as the ion source. A smart glove with integrated thermal sensor arrays is demonstrated, which endows a prosthetic hand with thermal sensation for potential applications in human-machine collaboration.